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Dr. Antoine H.F.M. Peters Friedrich Miescher Institute for Biomedical Research (FMI) Maulbeerstrasse 66 CH-4058 Basel Switzerland antoine.peters@fmi.ch Phone: 061 6978761 http://www.fmi.ch/peters.a/ |
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Antoine Peters is group leader at the Friedrich Miescher Institute for Biomedical Research in Basel. His group is interested in the epigenetic mechanisms that contribute to the heritability of cell identity of stem cells and during cellular differentiation as well as that safeguard genome stability. In particular, his group aims at understanding the role of and molecular interplay between histone methyltransferases, Polycomb group proteins and DNA methyltransferases in epigenetic (re)programming in mouse in-vitro systems as well as in pre-implantation and early post-implantation embryos. Towards these goals, his group performs gain- and loss-of-function studies in stem cells, in germ cells in which gene deficiency is induced at specific stages of their development, as well as in pre- and post-implantation embryos conditionally deficient for maternal and/or zygotic gene expression of epigenetic regulators. As functional readouts, the group analyzes the formation and function of heterochromatin, gene transcription, establishment and maintenance of genomic imprinting, nuclear organization, and cell fate. Antoine Peters is a selected member of the Network of Excellence "the Epigenome", a founding member of the Basel Stem Cell Network and a founding member of the Stem Cell Center of Competence. Since 2008, he is an EMBO Young Investigator. |
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| Research within the Node | |
| Within the SystemsX CellPlasticity research project, the Schwaller and Peters laboratories aim at understanding the molecular mechanisms underlying acute leukemia induced by the expression of leukemic fusion proteins. We combine genome-wide expression, transcription factor binding and epigenomic analyses with gain- and loss-of-function approaches to identify regulatory networks and pathways that are fundamental to the leukemic state. | |
Puschendorf, M., Terranova, R., Boutsma, E., Mao, X., Isono, K., Brykczynska, U, Kolb, C., Otte, A.P., Koseki, H., Orkin, S.O., van Lohuizen, M., and A.H.F.M. Peters (2008). PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nature Genetics 40(4): 411-420. This manuscript was featured in: Packer, A. (2008). Epigenetics: across the generations. Nat. Rev. Gen. 9: 248-249.
Terranova R., Yokobayashi S., Stadler M.B., Otte A.P., van Lohuizen M., Orkin S.H. and A.H.F.M. Peters (2008). Polycomb-group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Developmental Cell 15(5): 668-679. This manuscript was featured in: Wu, H.-U., and E. Bernstein: Partners in Imprinting: Noncoding RNA and Polycomb Group Proteins. Dev. Cell 15(5): 637-638.
Madan V., Madan B., Brykczynska U., Zilbermann F., Hogeveen K., Döhner K., Döhner H., Weber O., Blum C., Rodewald H.-R., Sassone-Corsi P., Peters A.H.F.M. and H.J. Fehling (2008). Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5. Blood 113(7): 1444-1454.
Reviews
Hublitz, P., Albert, M., and A.H.F.M. Peters (2009). Mechanisms of transcriptional repression by histone lysine methylation. International Journal of Developmental Biology. 53: 335-354 (part of special issue on Epigenetics).
Albert, M., and A.H.F.M. Peters (2009). Genetic and epigenetic control of early mouse development. Current Opinion in Genetics and Development 19: 113-121.